Diagnostic Code 6325 · 38 CFR §4.88b
Hyperinfection syndrome and disseminated strongyloidiasis are life-threatening complications of Strongyloides stercoralis infection, a parasitic roundworm acquired through skin contact with contaminated soil. Veterans who served in tropical or subtropical regions may carry a chronic silent Strongyloides infection for decades, because the parasite auto-infects its host. Hyperinfection occurs when the immune system is suppressed, allowing explosive parasite multiplication. The VA rates active disease at 100 percent with a mandatory follow-up examination after treatment.
| Rating | Criteria |
|---|---|
| 100% | Active hyperinfection syndrome or disseminated strongyloidiasis during treatment. The 100 percent rating continues through active disease, followed by a mandatory VA examination. |
| 0% | Resolved with no relapse confirmed on follow-up. Residual organ damage is rated under appropriate body system codes. |
Stool examination, sputum analysis, or tissue biopsy confirming Strongyloides. Serological testing. Deployment records to endemic regions. Documentation of immunosuppressive trigger if applicable. Imaging documenting dissemination. Post-treatment organ evaluations.
Strongyloides auto-infects its host, maintaining itself at low levels indefinitely. It only becomes dangerous when the immune system is suppressed.
Yes, especially before starting corticosteroids or other immunosuppressive medications. A simple blood test can detect the chronic infection.
Most commonly corticosteroid therapy, chemotherapy, or organ transplant immunosuppression. If the triggering medication was for a service-connected condition, the hyperinfection may qualify for secondary service connection.